#01
Aging Biology Research
MOTSC-10MG
Research compound
The certificate is public.
MOTS-c (Mitochondrial ORF of the 12S rRNA type-c) is a 16-amino acid mitochondrial-derived peptide (MDP) with the sequence MRWQEMGYIFYPRKLR. Unlike cell surface receptor-targeting peptides, MOTS-c functions as an intracellular retrograde signaling molecule transmitting metabolic information from mitochondria to the nucleus.
Available · 2 sizes
UPS Next Day Air — standard on every order
01Research context
MOTS-c represents a novel class of mitochondrial-derived peptides studied in metabolic and exercise physiology research. **Mechanism of Action (Research Context)**: - AMPK Activation: Primary mechanism involves folate cycle inhibition at 5-methyltetrahydrofolate (5Me-THF), leading to AICAR accumulation and AMP-activated protein kinase (AMPK) activation—the cellular "master switch" of metabolism - CK2 Interaction: Recent research (2025) identifies Casein Kinase 2 (CK2) as a direct target, relevant to skeletal muscle atrophy research - Osteogenic Pathways: AMPK-mediated osteoblast differentiation observed in bone metabolism studies **Research Considerations**: - Supplied as lyophilized powder requiring reconstitution - Known to be fragile and sensitive to agitation during preparation - Theoretical hypoglycemia risk due to rapid glucose disposal upon AMPK activation in research models - May interact with other AMPK activators (Metformin, Berberine) in research protocols **Regulatory Status**: Research compound. FDA Category 2 classification restricts compounding pharmacy use. For laboratory research only.
02Storage & handling
Lyophilized
Store sealed vials at −20 °C, protected from light.
Reconstituted
Refrigerate at 2–8 °C and use within the period stated on the COA.
Handling
Allow vials to reach room temperature before opening to avoid condensation.
Documentation
Every lot ships with a published certificate of analysis.
Research use only
This product is intended strictly for in-vitro research and laboratory use. Not for human or animal consumption, therapeutic use, or any form of in-vivo application.
Same research area
IMPORTANT:All products sold on this website are intended strictly for in-vitro research and laboratory use only. These products are NOT for human or animal consumption, therapeutic use, or any form of in-vivo application. Apex Peptides does not condone or promote any use outside of legitimate scientific research. Purchasers must be qualified researchers or institutions and assume all responsibility for compliance with applicable laws and regulations.
