#01
Metabolic Regulation Research
RETA-10MG
Research compound
The certificate is public.
GLP-3 RT (LY3437943) is a synthetic triple incretin receptor agonist peptide developed by Eli Lilly. It simultaneously targets GIP (Glucose-Dependent Insulinotropic Polypeptide), GLP-1 (Glucagon-Like Peptide-1), and Glucagon receptors—the "Triple G" mechanism. This 39-amino acid peptide represents the most advanced iteration of incretin-based research compounds, incorporating glucagon receptor agonism to potentially counteract metabolic adaptation.
Available · 5 sizes
UPS Next Day Air — standard on every order
01Research context
Retatrutide is an investigational compound currently in Phase 3 clinical trials (TRIUMPH program). It is NOT FDA approved. **Mechanism of Action (Research Context)**: - GLP-1R Agonism: Provides anorexigenic (appetite-suppressing) effects and delays gastric emptying in preclinical models - GIPR Agonism: High affinity binding (EC50 0.0643 nM) modulates lipid storage pathways and insulin sensitivity in laboratory studies - GCGR Agonism: The distinguishing feature—glucagon receptor activation drives lipolysis and thermogenesis, potentially counteracting metabolic rate reduction observed with caloric restriction **Published Research**: Phase 2 trial data (N Engl J Med, PMID: 35358490; JAMA, PMID: 36890743) describe significant metabolic effects including hepatic steatosis reduction (86% normalization at 48 weeks in research subjects). **Regulatory Status**: Investigational. Not approved for any indication. For laboratory research only.
02Storage & handling
Lyophilized
Store sealed vials at −20 °C, protected from light.
Reconstituted
Refrigerate at 2–8 °C and use within the period stated on the COA.
Handling
Allow vials to reach room temperature before opening to avoid condensation.
Documentation
Every lot ships with a published certificate of analysis.
Research use only
This product is intended strictly for in-vitro research and laboratory use. Not for human or animal consumption, therapeutic use, or any form of in-vivo application.
Same research area
IMPORTANT:All products sold on this website are intended strictly for in-vitro research and laboratory use only. These products are NOT for human or animal consumption, therapeutic use, or any form of in-vivo application. Apex Peptides does not condone or promote any use outside of legitimate scientific research. Purchasers must be qualified researchers or institutions and assume all responsibility for compliance with applicable laws and regulations.